RNA-Seq Dataset: Ubiquitin Signaling in Mtb-Infected Macrophages

RNA sequencing data from a study of Mycobacterium tuberculosis-infected macrophages. The dataset was generated by author Tina Truong to investigate the role of the ubiquitin ligase CBL in regulating antiviral and antibacterial immune responses. It includes mass spectrometry data identifying over 46,000 ubiquitylated peptides and was last updated on March 17, 2026.

Use Cases

• Identify differentially expressed genes in Mtb-infected macrophages based on RNA-Seq data.
• Analyze ubiquitin signaling pathways based on the identification of over 46,000 ubiquitylated peptides.
• Validate the role of specific adapter proteins like FAF2 in immune regulation based on genetic interaction analysis.
• Model the suppression of antiviral response genes by the CBL ubiquitin ligase.

Strengths

• Includes mass spectrometry data identifying over 46,000 ubiquitylated peptides.
• Focuses on a specific, well-defined biological system: Mycobacterium tuberculosis-infected macrophages.
• Data is shared under a permissive CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 7.7 MB file size suggests a relatively small dataset.

Provenance

Source

figshare

Collection Method

Likely generated from laboratory experiments involving RNA sequencing and mass spectrometry.

Time Range

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Freshness

Last updated 2026-03-17 17:36:39; freshness should be verified.

Geography

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