Hippocampal Gene Expression in Pilocarpine-Induced Status Epilepticus Mice

Featuring RNA sequencing results from a mouse model of status epilepticus (SE), identifying 366 differentially expressed genes (DEGs) at the 3-hour time point and 570 DEGs at the 24-hour time point. It was generated by Hui-Ling Tang to profile early transcriptional changes in the hippocampus following SE induction.

Use Cases

• Analyze the 366 DEGs from the SE-3h time point to identify initial transcriptional responses to status epilepticus.
• Investigate the 570 DEGs from the SE-24h time point, particularly those enriched in inflammatory and immune response GO functions.
• Examine specific DEGs like Tyrobp, C1qc, and Itgb2 for their role in the Microglia pathogen phagocytosis pathway and Tyrobp causal network.
• Compare up-regulated gene sets between SE-3h and SE-24h time points to study the progression of microglia-mediated inflammatory responses.

Strengths

• Identifies a specific number of differentially expressed genes: 366 at SE-3h and 570 at SE-24h.
• Focuses on two defined, early time points (3h and 24h post-SE) crucial for studying acute brain damage.
• Includes bioinformatic enrichment results for functional pathways like Microglia pathogen phagocytosis.

Limitations

• The dataset is very small at 12.4 KB, indicating limited scope and likely summary-level data rather than raw sequencing reads.
• Data is from a specific animal model (pilocarpine-induced SE mice), limiting direct applicability to human epilepsy.
• The exact number of biological replicates or samples is unknown, which affects statistical assessment.

Provenance

Source

Hui-Ling Tang via figshare.

Collection Method

RNA sequencing of hippocampal tissue from pilocarpine-induced status epilepticus mice at 3-hour and 24-hour time points.

Time Range

Experimental time points: 3 hours and 24 hours post-status epilepticus induction.

Freshness

Last updated on 2026-03-20.