RT-qPCR Data for Spinal Cord Injury Hub Genes Soat1, Comt, and Myo1f

RT-qPCR data for selected hub genes was published by author Xiaowei Zha on figshare in May 2026. The 10.6 KB Excel file contains validation data for three hub genes (Soat1, Comt, Myo1f) identified as associated with macrophage polarization in spinal cord injury. The dataset is licensed under CC-BY-4.0.

Use Cases

• Validate machine learning-derived hub gene expression based on RT-qPCR data mentioned in the description
• Correlate gene expression with immune infiltration profiles based on the 11 immune gene sets referenced
• Identify potential therapeutic targets based on the 37 predicted small molecules, including dexamethasone and atorvastatin
• Compare gene expression between M1 and M2 macrophage subtypes based on single-cell RNA sequencing results mentioned

Strengths

• Data is validated via RT-qPCR, a standard experimental method
• Includes three specific hub genes (Soat1, Comt, Myo1f) identified through multiple machine learning algorithms (LASSO, RF, XGBoost)
• Released under a permissive CC-BY-4.0 license for reuse

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is very small (10.6 KB), indicating limited scope

Provenance

Source

figshare

Collection Method

Experimental RT-qPCR validation of bioinformatically identified hub genes

Time Range

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Freshness

Last updated 2026-05-04 17:30:36; freshness should be verified

Geography

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