RT-qPCR Primers List for Osteoporosis and Chronic Kidney Disease Hub Genes

Four hub genes (FAM184A, NFKBIA, RP2, HIRA) were identified as links between osteoporosis and chronic kidney disease. This 5.5 KB Excel file contains the RT-qPCR primers list used for experimental validation in mouse models. Hao Tang published the dataset under a CC-BY-4.0 license on figshare in May 2026.

Use Cases

• Validate hub gene expression in osteoporosis and chronic kidney disease models based on the RT-qPCR primers list.
• Assess diagnostic performance of identified genes based on the ROC curve analysis described.
• Explore potential therapeutic agents for comorbid conditions based on the Drug Signatures Database (DSigDB) investigation.
• Analyze immune infiltration relationships based on the CIBERSORT analysis of hub genes and immune cells.

Strengths

• Dataset is focused on four specific hub genes (FAM184A, NFKBIA, RP2, HIRA) with validated diagnostic performance.
• Experimental validation was conducted using cisplatin-induced CKD and ovariectomy-induced osteoporosis mouse models.
• Data is openly shared under a permissive CC-BY-4.0 license.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The dataset is very small at 5.5 KB, indicating a limited scope focused primarily on the primer list.
• Data may reflect the specific experimental and bioinformatics analysis bias inherent to the source study.

Provenance

Source

figshare, authored by Hao Tang.

Collection Method

Primers list generated from bioinformatics analysis and experimental validation via RT-qPCR.

Time Range

Publication date is 2026-05-04.

Freshness

Last updated 2026-05-04 17:35:52; freshness should be verified.

Geography

Study likely involves data from GEO databases and experiments on C57BL/6J mice; specific geography is unknown.