S6 Fig 3: In Vivo and In Vitro Data on Astragaloside IV Effects on Peritoneal Fibrosis

Astragaloside IV treatment was associated with a significant attenuation of peritoneal fibrosis in a uremic rat model and human peritoneal mesothelial cells. The 21.3 KB XLSX file contains data from a study investigating the ENKUR/PI3K/Akt signaling pathway. Author Tianxin Jiang published the dataset on figshare under a CC-BY-4.0 license.

Use Cases

• Analyze the correlation between ENKUR, pPI3K, and pAkt downregulation and fibrosis marker reduction based on the described in vivo results.
• Investigate the effects of Astragaloside IV on extracellular matrix deposition and collagen accumulation mentioned in the study.
• Model the suppression of epithelial-mesenchymal transition in human peritoneal mesothelial cells based on the described in vitro approach.
• Validate the proposed antifibrotic mechanism via the ENKUR/PI3K/Akt pathway using the provided experimental data.

Strengths

• Dataset is openly licensed under CC-BY-4.0, permitting reuse and redistribution.
• Study design includes both in vivo (uremic rat model) and in vitro (human cell) approaches, as described.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 21.3 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Data likely generated from laboratory experiments on uremic rats and human peritoneal mesothelial cells, as described.

Freshness

Last updated 2026-05-08 17:38:48; freshness should be verified.