Sera from circVB16T13-immunized mice confer effective protection in neonatal rat pups

Pooled sera from mice immunized with a circular vaccine candidate (circVB16T13) were tested for protective efficacy against Neisseria meningitidis strain MC58 in Wistar rat pups. The dataset, authored by Qiqi Zhang and last updated on 2026-05-11, compares bacterial loads in blood after passive transfer of sera from mock, low-dose, and protein-immunized groups. Results show high serum bactericidal activity (hSBA) titers of 646 and 701 in immunized groups, with undetectable bacteria in some samples.

Use Cases

• Compare vaccine efficacy based on serum bactericidal activity (hSBA) titers mentioned in the description
• Analyze bacterial load reduction in neonatal models after passive serum transfer
• Evaluate dose-response relationships using data from low-dose (15 μg) and protein (20 μg) immunization groups

Strengths

• Directly compares three immunization groups (mock, low-dose circVB16T13, protein-immunized) with specific hSBA titers
• Includes a clear experimental time point: blood bacteria loads measured 3 hours after challenge
• Dataset is openly licensed under CC-BY-4.0

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Dataset is very small (5.5 KB), indicating limited scope

Provenance

Source

figshare

Collection Method

Experimental data from a passive immunization study in mice and rat pups.

Freshness

Last updated 2026-05-11 18:00:46; freshness should be verified