SFI Summary: Rat Sciatic Nerve Repair Outcomes with PEG-Fusion

1.8 MB of data from a study using Lewis rats to test polyethylene glycol (PEG)-fusion for repairing 4-mm and 8-mm segmental-loss sciatic nerve injuries. The dataset, authored by Cathy Z. Yang and last updated in May 2026, includes Sciatic Functional Index (SFI) scores and likely contains axonal morphology measurements from groups treated with and without PEG-fusion and FK506. It was shared under a CC-BY-4.0 license on figshare.

Use Cases

• Compare behavioral recovery outcomes based on Sciatic Functional Index (SFI) scores between PEG-fusion and control groups.
• Analyze the relationship between axonal diameter and g-ratio measurements mentioned in the description.
• Investigate the effect of localized FK506 treatment on long-term functional recovery after nerve graft repair.
• Model the impact of graft length (5-mm vs. 10-mm) on Wallerian degeneration and regeneration success.

Strengths

• Data is from a controlled animal model study with genetically identical Lewis rats, reducing genetic variability.
• Explicitly compares two distinct repair gap lengths (4-mm and 8-mm) and two treatment solutions (with and without 50% w/w 3.35 kDa PEG).
• Includes a key behavioral metric, the Sciatic Functional Index (SFI), described as the most important measure of successful repairs.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is stored in the proprietary PZFX file format, which may require specific software (e.g., GraphPad Prism) for access.

Provenance

Source

Cathy Z. Yang, shared via figshare.

Collection Method

Experimental data from sciatic nerve injury and repair surgeries on Lewis rat models, with subsequent morphological and behavioral assessment.

Freshness

Last updated 2026-05-21 17:22:47; freshness should be verified.