Significantly Associated Genes in TWAS Analysis for Age-Related Eye Disease

11 genome-wide significant loci were identified for Age-related eye disease (ARED) using Genomic Structural Equation Modeling and post-processing of GWAS. The research by Luqi Gao presents a genetic landscape of ARED by analyzing tissue-, cell layer-, and genomic element-associated gene signals. The dataset, last updated in May 2026, is available as an 11.2 KB XLSX file under a CC-BY-4.0 license.

Use Cases

• Prioritize candidate SNPs for functional validation based on statistically prioritized loci.
• Investigate tissue-specific gene expression patterns linked to age-related ocular vulnerabilities.
• Annotate functional roles of identified genes in relation to ARED pathogenesis.
• Compare results from diverse transcriptome-wide association approaches for methodological validation.

Strengths

• Identifies 11 genome-wide significant loci for Age-related eye disease.
• Applies multiple analytical approaches including Genomic-SEM and diverse TWAS methods.
• Provides functional annotations for gene signals related to ocular vulnerabilities.

Limitations

• The dataset is very small at 11.2 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare, author Luqi Gao.

Collection Method

Generated using Genomic Structural Equation Modeling (Genomic-SEM) and post-processing analysis of Genome-Wide Association Studies (GWAS).

Freshness

Last updated 2026-05-14 17:48:54; freshness should be verified.