Similar Contacts of HLA DR and DQ Complexes: 81 Protein Structures

81 peptide-HLA II DR and DQ complexes, including CLIP-HLA II, were selected from the PDB database. Alexander E. Kister created this dataset, which introduces 'Unified Residue Numbering' to compare residue contacts across complexes. The data, last updated on April 10, 2026, may be useful for refining computational algorithms that predict peptide interactions with HLA II complexes.

Use Cases

• Identifying common anchoring residue contacts across HLA II complexes based on the 'similar contacts' analysis.
• Refining peptide-HLA II interaction prediction algorithms based on structural and physicochemical characteristics of anchoring contacts.
• Comparing peptide-HLA II contact maps to the CLIP-HLA II reference structure using the unified residue numbering scheme.

Strengths

• Dataset includes 81 diverse peptide-HLA II DR and DQ complexes.
• Analysis found 90% of peptide-alpha chain contacts and 80% of peptide-beta chain contacts were 'similar contacts'.
• Dataset employs a 'Unified Residue Numbering' system enabling cross-complex comparison.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Dataset size is 17.5 KB, indicating a limited scope of data.

Provenance

Source

PDB database

Collection Method

81 complexes were selected and analyzed with introduced 'Unified Residue Numbering'.

Freshness

Last updated 2026-04-10 17:51:18; freshness should be verified.