Courtney Lucas published a dataset on figshare in March 2026 containing single nucleotide variants (SNVs) for 15 genes. The 13.5 KB XLS file likely contains results from TaqMan genotyping and logistic regression analyses investigating associations between genetic polymorphisms and temporomandibular symptoms, periodontitis, and systemic inflammatory diseases. The study applied Bonferroni correction for statistical significance.
Use Cases
- Identify genetic associations between specific SNVs and systemic inflammatory diseases based on the described allelic association tests.
- Analyze potential links between polymorphisms in genes like MMP9 and AXIN2 and oral disease phenotypes as described in the results.
- Replicate or validate logistic regression models for systemic and dental disease phenotype associations mentioned in the methodology.
Strengths
- Focuses on 15 specific genes (e.g., ADAM10, IL10, MMP9) relevant to inflammation.
- Statistical analysis applied Bonferroni correction with a significance threshold of α=0.001.
- Data is openly available under a CC-BY-4.0 license.
Limitations
- Row count is unknown, which may limit suitability assessment.
- Column-level documentation is absent; field semantics must be inferred after download.
- The dataset is very small at 13.5 KB, indicating limited scope.
Provenance
- Source
- figshare, author Courtney Lucas.
- Collection Method
- SNVs were selected for TaqMan chemistry genotyping; phenotypes were identified by querying repository records.
- Time Range
- null
- Freshness
- Last updated 2026-03-25 17:36:23; freshness should be verified.
- Geography
- null