Plasmodium Pyrimidine Biosynthesis Enzyme Essentiality Data

Source data for all graphs in a study investigating essential enzymes in the pyrimidine biosynthesis pathway of the malaria parasite Plasmodium falciparum. The dataset, authored by Krithika Rajaram and last updated in May 2026, is shared under a CC-BY-4.0 license on figshare.

Use Cases

• Validate the essentiality of PfATC, PfCPSII, and PfDHO enzymes based on experimental knockdown and deletion results.
• Analyze the functional role of the PfATC N-terminal domain based on complementation assay data.
• Assess the potential for uracil salvage as a metabolic bypass based on data from engineered parasite lines.
• Compare the vulnerability of different nodes within the pyrimidine biosynthesis pathway.

Strengths

• Data underpins a peer-reviewed study on essential metabolic enzymes in a major human pathogen.
• Shared under a permissive CC-BY-4.0 license, facilitating reuse.
• File size is 56.5 KB, making it quick to download and inspect.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from genetic manipulation and complementation assays described in the associated study.

Freshness

Last updated 2026-05-27 17:44:08; freshness should be verified.