Three-Season Influenza Vaccine Immune Response Data

A three-season (2022–2025) study of 1,328 participants aged 9–89 years receiving six different influenza vaccine types. Serum samples were tested for hemagglutination inhibition (HAI) activity against vaccine and historical strains before and after vaccination. The dataset, authored by Engin Berber and shared on figshare, analyzes seroprotection and seroconversion rates by age group and vaccine platform.

Use Cases

• Compare antibody response (HAI titers) based on vaccine platform (e.g., Fluzone SD vs. Flublok)
• Analyze seroconversion and seroprotection rates by age group (9–89 years)
• Study the effect of repeated annual vaccination on immune boosting and back-boosting
• Evaluate differences in immune response between standard-dose, high-dose, adjuvanted, and live-attenuated vaccines
• Model HAI titer waning over time, especially in elderly participants (≥65 years)

Strengths

• Includes 1,328 participants, providing a substantial sample size
• Covers three consecutive seasons (2022–2025), allowing longitudinal analysis
• Compares six distinct vaccine types (Fluzone SD/HD, Fluad, Flucelvax, Flublok, Flumist)
• Contains pre- and post-vaccination (day 28) serum HAI measurements

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Data may reflect temporal bias inherent to the specific three-season study period

Provenance

Source

figshare

Collection Method

Clinical study collecting serum samples and testing for HAI activity.

Time Range

2022–2025

Freshness

Last updated 2026-04-16 17:37:32; freshness should be verified