Seasonal Influenza Vaccine Immune Responses Across Three Seasons

A three-season (2022–2023–2024–2025) study of 1,328 participants aged 9–89 years receiving six vaccine types. Serum samples were tested for hemagglutination inhibition (HAI) activity against vaccine and historical strains before and after vaccination. The dataset was authored by Engin Berber and published on figshare.

Use Cases

• Compare seroprotection and seroconversion rates based on vaccine platform and recipient age.
• Analyze the association between repeated annual vaccination and reduced HAI boosting to current vaccine strains.
• Evaluate differences in post-vaccination HAI titers between younger adults and elderly participants.
• Assess the performance of specific vaccine formulations (e.g., Flublok vs. Fluzone SD) against H1N1 and H3N2 strains.

Strengths

• Includes data from 1,328 participants across a wide age range (9–89 years).
• Covers three consecutive influenza seasons (2022–2023–2024–2025).
• Tests six different vaccine types and includes pre- and post-vaccination serum HAI measurements.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is relatively small (338.4 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Serum samples collected from vaccinated participants and tested for HAI activity.

Time Range

2022–2023–2024–2025

Freshness

Last updated 2026-04-16 17:37:37; freshness should be verified.