Ancylostoma ceylanicum Gene Overlap Statistics for Immunoregulated Proteins

Statistical analyses of overlaps between genes encoding protein domains and genes encoding excretory/secretory proteins with positively immunoregulated expression in 19-day-old hookworm intestines. The dataset, shared under a CC-BY-4.0 license by Erich M. Schwarz, includes p-values and q-values for these overlaps, as well as pairwise comparisons with other gene categories like 'Male-biased'. It was last updated on March 17, 2026.

Use Cases

• Identify protein domains significantly associated with immunoregulatory excretory/secretory proteins based on statistical overlap tests.
• Compare the positively immunoregulated intestinal ES gene set against other functional categories like 'Male-biased' genes.
• Prioritize candidate genes for further functional validation in hookworm vaccine or drug target discovery.

Strengths

• Dataset is openly licensed under CC-BY-4.0.
• Statistical significance of gene overlaps is explicitly calculated and reported with p-values and q-values.
• Includes pairwise comparisons with additional gene categories beyond the main domain analysis.

Limitations

• Row count and specific column definitions are unknown, requiring inspection after download.
• The 702.2 KB file size suggests a limited scope of data.

Provenance

Source

figshare

Collection Method

Statistical analysis of gene expression and protein domain data, likely derived from prior experimental studies.

Freshness

Last updated 2026-03-17 17:34:45.