Sterol Levels of Test Diets for Stroke-Prone Hypertensive Rats

A figshare dataset by Yutaro Nishikata, last updated in May 2026, containing sterol and lipid profile data from a controlled animal study. The 5.5 KB XLS file documents sterol content, fatty acid composition, and prostaglandin E2 levels in serum and tissues of SHRSP rats fed cholesterol-enriched diets for 12 weeks. The data supports the study's findings linking dietary cholesterol to reduced blood pressure and altered renal lipid profiles.

Use Cases

• Analyzing the relationship between dietary cholesterol and systolic blood pressure based on the reported 9–10% reduction.
• Studying changes in organ-specific lipid profiles, including phytosterol content and arachidonic acid ratios, as described in the study.
• Investigating the suppression of the AA-PGE2 axis in kidney and liver tissues based on the measured prostaglandin E2 levels.
• Correlating dietary interventions with renal histopathology outcomes based on the described attenuation of glomerular inflammation.

Strengths

• Data is associated with a specific, peer-reviewed experimental design involving three distinct diet groups and a 12-week feeding period.
• Includes measurements of multiple biological endpoints: sterol content, fatty acid composition, prostaglandin E2 levels, and histopathology.
• Dataset is openly licensed under CC-BY-4.0, permitting reuse with attribution.

Limitations

• The dataset is very small at 5.5 KB, indicating limited scope and likely a small number of observations.
• Column-level documentation is absent; field semantics must be inferred from the description after download.
• Row count is unknown, which may limit suitability assessment for statistical modeling.

Provenance

Source

Yutaro Nishikata via figshare.

Collection Method

Data collected from a controlled laboratory experiment using SHRSP/Izm rats assigned to three dietary groups.

Time Range

The experimental feeding period lasted 12 weeks; specific calendar dates are not provided.

Freshness

Last updated 2026-05-21 17:27:00; freshness should be verified.