Cryptococcus Neoformans Strains and CO2 Tolerance Mutant Screen

A list of Cryptococcus neoformans strains used in a study of genetic determinants of CO2 tolerance, a key virulence trait. The dataset includes results from a near genome-wide screen of 4,692 deletion mutants, identifying 301 with altered fitness under high CO2 conditions. It was authored by Laura C. Ristow and last updated in May 2026.

Use Cases

• Identifying genes essential for CO2 tolerance in Cryptococcus neoformans based on the mutant screen results.
• Studying the link between central carbon metabolism and fungal virulence suggested by the integrated response model.
• Investigating the role of the TOR-Ypk1 signaling axis in fungal stress adaptation based on the study's findings.
• Analyzing genetic determinants of membrane homeostasis under host-like environmental conditions.

Strengths

• Data is derived from a near genome-wide screen of 4,692 deletion mutants.
• Identifies 301 specific mutants (245 with reduced fitness, 56 with increased fitness) with altered CO2 tolerance.
• Dataset is associated with a specific, detailed biological study and model for CO2 adaptation.

Limitations

• Row count and specific column-level documentation are unknown, requiring manual inspection after download.
• The dataset is very small (9.8 KB), indicating limited scope, likely containing only strain lists or summary results.
• Description metadata is limited; actual data quality and completeness require verification.

Provenance

Source

figshare, authored by Laura C. Ristow.

Collection Method

Data likely generated from a competitive growth assay screen of a C. neoformans deletion mutant library.

Freshness

Last updated 2026-05-05 17:37:24.