Listeria Strains with Mutations in Stress Response Operon

Strains used in a study investigating genetic plasticity in the general stress response of the foodborne pathogen Listeria monocytogenes. The dataset includes acid-resistant derivatives with specific mutations in the sigB operon, such as rsbX N77K and rsbU Q317*, and mutations affecting the rsbW start codon. It was authored by Jialun Wu and published on figshare in April 2026.

Use Cases

• Correlate specific rsbX and rsbU mutations with changes in SigB activity and bacterial fitness.
• Analyze the impact of non-canonical rsbW start codons (ATA, ATT) or premature termination on acid resistance phenotypes.
• Compare strain genotypes, like rsbW start codon variants, to virulence and stress response gene expression levels.
• Use strain mutation profiles to model short-term adaptation to lethal acidic challenge mimicking host entry.

Strengths

• Data is derived from a defined clinical isolate with a complete genome sequence.
• Includes analysis of 6 distinct acid-resistant derivative (ARD) strains.

Limitations

• Dataset is very small at 5.5 KB, containing only the strains used in a single study.
• Limited to mutations within the sigB operon, not a genome-wide mutation catalog.
• Sample size of analyzed ARDs is only 6, limiting statistical power.

Provenance

Source

Jialun Wu via figshare.

Collection Method

Strains generated and sequenced for a specific study on SigB regulation and acid resistance adaptation.

Freshness

Last updated April 2026.