Ranibizumab Pharmacokinetics in the Human Eye from Computational Model Simulations

A 5.5 KB Excel file contains summary data from a computational pharmacokinetic model of ranibizumab in the human eye. The model, developed by Jabia Mostofa Chowdhury in COMSOL Multiphysics 6.3, simulated four physiological scenarios to predict intravitreal half-lives and drug concentration near the macula. The dataset was last updated on May 7, 2026.

Use Cases

• Validate computational pharmacokinetic models against reported human half-life data (2.4–9 days) based on the model's predicted range (2.7–4.4 days).
• Explore dosing strategies for intravitreal injections based on simulated drug concentration near the macula.
• Compare drug elimination pathways by analyzing results from the four simulated physiological scenarios (vitreous state and elimination routes).
• Inform the design of intravitreal drug delivery systems using the provided computational framework.

Strengths

• Model predictions (2.7–4.4 day half-lives) are consistent with reported human experimental data (2.4–9 days).
• The dataset is licensed under CC-BY-4.0, permitting open sharing and adaptation.
• The computational model quantifies drug concentration at a specific anatomical target site (the macula).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (5.5 KB), indicating it likely contains summary or parameter data rather than raw simulation outputs.

Provenance

Source

figshare, author Jabia Mostofa Chowdhury

Collection Method

Results from a three-dimensional computational fluid dynamics model developed in COMSOL Multiphysics.

Time Range

Simulation study; specific temporal coverage not stated.

Freshness

Last updated 2026-05-07 17:29:01; freshness should be verified.

Geography

Model of the human eye; geographic scope not specified.