HIV Testing Strategies for Long-Acting PrEP: A Systematic Review

A systematic review of 22 studies across 15 countries evaluates HIV testing strategies for long-acting injectable pre-exposure prophylaxis (LAI-PrEP). The dataset includes findings from 7,698 records and data from a WHO survey, analyzing outcomes for 8,171 LAI-PrEP users. It was authored by Warittha Tieosapjaroen and updated in April 2026.

Use Cases

• Compare HIV detection rates between rapid diagnostic tests and nucleic acid testing based on trial data
• Analyze cost and turnaround time differences between laboratory-based tests and RDTs
• Evaluate the risk of delayed HIV detection and false-positive results associated with different testing methods
• Assess the clinical and programmatic outcomes of HIV testing for cabotegravir and lenacapavir LAI-PrEP

Strengths

• Includes data from 22 studies across 15 countries
• Analyzes outcomes for 8,171 LAI-PrEP users from four randomized controlled trials
• Compares specific test costs (US$4 versus US$22) and turnaround times (same-day versus up to 7 days)
• Incorporates findings from a World Health Organization survey

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The overall certainty of evidence reported in the review is low

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis supplemented by WHO survey data

Time Range

Studies retrieved up to April 8, 2025

Freshness

Last updated 2026-04-16 18:00:24; freshness should be verified

Geography

15 countries