Summary of OspA-Fab Interactions: Lyme Disease Vaccine Research Data

A panel of isogenic Borrelia burgdorferi reporter strains expressing seven major OspA serotypes was developed to evaluate monoclonal antibodies. Structural analysis of Fabs in complex with OspA ST1 identified overlapping epitopes and a key susceptibility determinant, Lys-107. This 5.5 KB Excel dataset by Graham G. Willsey, last updated in April 2026, supports structure-based vaccine design.

Use Cases

• Classifying monoclonal antibody borreliacidal activity based on OspA serotype susceptibility profiles.
• Mapping antibody epitopes based on structural analysis of Fab-OspA complexes.
• Identifying conserved residues for vaccine design based on the analysis of Lys-107 as a susceptibility determinant.

Strengths

• Data is derived from a defined panel of seven major OspA serotypes (ST1–7).
• Includes structural analysis of Fabs from three distinct antibody classes.
• Dataset is licensed under CC-BY-4.0, permitting open reuse.

Limitations

• Dataset is very small at 5.5 KB, indicating limited scope.
• Row count and column-level documentation are unknown.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from probing reporter strains with monoclonal antibodies and subsequent structural analysis.

Freshness

Last updated 2026-04-21 17:52:18; freshness should be verified.