Genetic Associations Between Systemic Inflammation and Oral Disease Phenotypes

15 genes were analyzed for associations between their single nucleotide variants and phenotypes of temporomandibular symptoms and periodontitis. The study identified significant associations for SNPs in MMP9 and AXIN2 with systemic inflammatory diseases like asthma and rheumatoid arthritis. This 5.5 KB dataset was authored by Courtney Lucas and last updated in March 2026.

Use Cases

• Identify genetic markers for temporomandibular disorder risk based on SNP associations in MMP9 and AXIN2.
• Assess shared genetic predisposition for systemic and oral inflammatory diseases based on allelic association tests.
• Validate candidate genes for preventive dental medicine based on the 15 selected genes (ADAM10, AQP5, etc.).
• Perform replication studies for SNP-phenotype associations using the provided logistic regression results.

Strengths

• Focus on 15 specific candidate genes relevant to inflammation.
• Statistical significance denoted using Bonferroni correction (α = 0.001).
• Data is openly available under a CC-BY-4.0 license.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 5.5 KB, indicating limited scope.

Provenance

Source

figshare, authored by Courtney Lucas.

Collection Method

Data generated via TaqMan chemistry genotyping and analysis using gPLINK from queried repository records.

Time Range

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Freshness

Last updated 2026-03-25 17:36:27; freshness should be verified.

Geography

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