T Cell Panel: Single-Cell RNA/TCR Sequencing Data from Malaria-Exposed Lymphoid Organoids

Single-cell RNA and T cell receptor sequencing data from human tonsil and spleen organoids exposed to Plasmodium falciparum malaria parasites. The dataset, 5.5 KB in size, was created by Kathleen D. Press and last updated on April 10, 2026. It captures clonal expansion and cytotoxic phenotypes of Vδ2+ γδ T cells in response to malaria infection.

Use Cases

• Analyzing Vδ2+ γδ T cell clonal expansion based on TCR repertoire data mentioned in the description
• Characterizing cytotoxic T cell phenotypes based on upregulated granzyme and interferon-stimulated gene expression
• Comparing immune responses in malaria-exposed versus malaria-naïve organoid models
• Validating findings from organoid models against tonsil samples from Ugandan children with asymptomatic parasitemia

Strengths

• Data is derived from single-cell RNA/TCR sequencing, a high-resolution technique.
• Includes validation from human tonsil samples from Ugandan children.
• Released under a permissive CC-BY-4.0 license.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 5.5 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Generated from experimental exposure of human tonsil and spleen organoids to Plasmodium falciparum-infected red blood cells, followed by single-cell sequencing.

Time Range

null

Freshness

Last updated 2026-04-10 18:00:25; freshness should be verified.

Geography

Organoid donors were malaria-naïve; validation samples are from Ugandan children.