Ketogenic Diet Feed Formulations for a Mouse Model of Autoimmune Thyroiditis

5.5 KB of experimental data on ketogenic diet formulations and outcomes in a mouse model of autoimmune thyroiditis. The dataset, authored by Yue Luo and last updated in May 2026, contains results from a study where 60 NOD.H-2h4 mice were randomized into three dietary and disease model groups. It likely includes measurements of thyroid antibodies, cytokines, oxidative stress markers, and gene expression related to immune pathways.

Use Cases

• Analyzing the effect of a ketogenic diet on thyroid autoantibody levels (TgAb/TPOAb) in an iodine-induced autoimmune model.
• Investigating the relationship between diet and proinflammatory cytokine profiles (MCP-1, TNF-α, IL-1β, IL-6, IL-18, IFN-γ).
• Studying the modulation of oxidative stress markers (MDA, SOD, T-AOC) by dietary intervention.
• Examining gene expression changes in NLRP3 inflammasome components (NLRP3, ASC, Caspase-1) and Th17/Treg-related factors (RORγt, IL-17, FoxP3, IL-10) under different diets.
• Modeling the impact of ketogenic diet on HMGB1/TLR2/4/NF-κB signaling pathways in autoimmune thyroiditis.

Strengths

• Data originates from a controlled animal study with 60 mice across three defined experimental groups.
• The description details a wide range of measured outcomes including histopathology, serum markers, cytokines, and gene expression.
• Dataset is shared under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• The dataset is very small at 5.5 KB, indicating limited scope and likely a summary of results rather than raw experimental data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for statistical modeling.

Provenance

Source

figshare, author Yue Luo.

Collection Method

Data generated from a laboratory experiment on NOD.H-2h4 mice, involving dietary intervention and biochemical/histological analysis.

Freshness

Last updated 2026-05-08 17:49:37; freshness should be verified.