Feed Formulations for a Mouse Study on Ketogenic Diet and Autoimmune Thyroiditis

A 2026 study by Yue Luo investigated the effects of a ketogenic diet on iodine-induced autoimmune thyroiditis in NOD.H-2h4 mice. The dataset, shared on figshare, contains feed formulations used in the experiment, which included normal and ketogenic diets. The study measured outcomes such as thyroid histopathology, serum antibodies, inflammatory cytokines, and oxidative stress markers.

Use Cases

• Replicate dietary interventions in murine autoimmune models based on the described feed formulations.
• Analyze the relationship between diet type and immunological markers like TgAb/TPOAb levels mentioned in the study.
• Study the modulation of inflammatory pathways such as HMGB1/NLRP3 and Th17/Treg balance through dietary data.
• Correlate specific diet compositions with oxidative stress markers like MDA and SOD activity described in the results.

Strengths

• Dataset is associated with a controlled animal study involving 60 mice across three experimental groups.
• The underlying research measured a wide range of biological endpoints, including histopathology, serum cytokines, and gene expression.
• Data is shared under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• The dataset is very small at 5.5 KB, suggesting it contains only summary formulations or a limited number of records.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for statistical analysis.

Provenance

Source

figshare, authored by Yue Luo.

Collection Method

Data generated from a controlled laboratory experiment on mice.

Time Range

The study was published in 2026.

Freshness

Last updated 2026-05-08 17:49:35; freshness should be verified.