m5C mRNA Methylation in Hedgehog Pathway Genes, NMDA vs Control

A dataset from figshare provides m5C methylation information for Ihh, Gli1, and Gli2 mRNAs within the Hedgehog signaling pathway. It compares methylation patterns between an NMDA-treated group and a control group, generated via MeRIP-seq. The dataset was authored by Yahong Li and last updated on April 15, 2026.

Use Cases

• Identify differential m5C methylation sites in Hedgehog pathway genes based on NMDA treatment.
• Correlate mRNA methylation changes with Hedgehog signaling activity based on the described experimental groups.
• Validate or compare MeRIP-seq findings for m5C modifications in specific target mRNAs.

Strengths

• Data is shared under a permissive CC-BY-4.0 license.
• The dataset is small (5.5 KB), facilitating quick download and inspection.
• A specific biological comparison (NMDA vs. control) is clearly defined.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare, author Yahong Li

Collection Method

Data likely derived from MeRIP-seq (Methylated RNA Immunoprecipitation Sequencing) experiments.

Freshness

Last updated 2026-04-15 17:46:56; freshness should be verified.