MS Parameters: Plasma Metabolomic Profiles for EGPA and Asthma Patients

Songsen Su published metabolomic data comparing patients with eosinophilic granulomatosis with polyangiitis (EGPA), bronchial asthma (BA), and healthy controls. The dataset contains results from untargeted liquid chromatography/mass spectrometry (LC/MS) analysis, identifying 971 differentially expressed metabolites between EGPA patients and healthy controls. It was last updated on May 12, 2026.

Use Cases

• Identify diagnostic biomarkers for EGPA based on differential metabolite expression.
• Compare metabolic pathways between EGPA and bronchial asthma patients.
• Validate candidate biomarkers using ROC curve analysis results mentioned in the description.
• Explore metabolic dysregulation in autoimmune disease pathogenesis.

Strengths

• The study identified 971 differentially expressed metabolites between EGPA patients and healthy controls.
• ROC curve analysis demonstrated 21 metabolites with strong diagnostic performance (AUC > 0.8).
• The dataset is licensed under CC-BY-4.0, allowing for open reuse.

Limitations

• The dataset is very small at 5.5 KB, indicating limited scope.
• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The sample size is limited to 10 patients per group (EGPA, BA, HCs).

Provenance

Source

figshare

Collection Method

Untargeted metabolomics based on liquid chromatography/mass spectrometry (LC/MS) performed on plasma samples from 30 subjects.

Freshness

Last updated 2026-05-12 17:39:27; freshness should be verified.