Paraben-HNSCC Molecular Targets and Hub Genes

80 common molecular targets were identified linking six parabens to head and neck squamous cell carcinoma. The analysis highlights 12 hub genes, including CCNB1 and CDK1, enriched in cell cycle and p53 signaling pathways. Lei Zhao published this toxicology dataset in 2026, providing results from network analysis and molecular docking.

Use Cases

• Identify potential toxicological targets by analyzing the 80 common paraben-HNSCC targets from Swiss Target Prediction and ChEMBL
• Validate hub gene overexpression using the 12 identified genes like CCNA1 and CDK1 for survival and immune infiltration analysis
• Perform molecular docking simulations based on the strong binding affinities reported between parabens and hub proteins
• Conduct functional enrichment analysis on the target set for pathways such as cell cycle regulation and viral carcinogenesis

Strengths

• Identifies 80 specific molecular targets connecting parabens to HNSCC carcinogenesis
• Focuses on 12 validated hub genes with detailed functional enrichment results
• Results are derived from integrated analysis using ProTox 3.0, TCGA-HNSC data, and molecular docking tools
• Dataset is openly shared under a CC BY 4.0 license

Limitations

• Dataset size is only 111.2 KB, indicating limited raw data or summary-level results only
• Underlying row counts and column structures for the analysis inputs are not provided
• Findings are computational and require experimental validation as noted in the study conclusions

Provenance

Source

Analysis by Lei Zhao, published on figshare.

Collection Method

Integrated network toxicology using ProTox 3.0, ADMETlab2.0, Swiss Target Prediction, ChEMBL, SEA, GeneCards, OMIM, CTD, and TCGA-HNSC data.

Freshness

Last updated in March 2026.