Hematopoietic Cell Transplant Outcomes for Sickle Cell Disease

A historical cohort study analyzes transplant outcomes, including graft-versus-host disease (GVHD) and post-transplant lymphoproliferative disorder (PTLD), for patients with sickle cell disease (SCD). The dataset compares outcomes between haplo-1 and haplo-PC transplant protocols, with statistical analyses based on Wilcoxon rank-sum and Fisher's exact tests. It was authored by Emily Limerick and is available under a CC BY 4.0 license.

Use Cases

• Compare overall survival and disease-free survival rates between haplo-1 and haplo-PC transplant protocols.
• Analyze the incidence of graft-versus-host disease (GVHD) and post-transplant lymphoproliferative disorder (PTLD) as key transplant complications.
• Investigate the return of sickle cell disease (SCD) as a primary outcome measure following hematopoietic cell transplant.
• Assess the development of immune cytopenias, such as autoimmune hemolytic anemia (AIHA), within the patient cohort.

Strengths

• Dataset provides specific outcome statistics, such as a 14% event rate for the haplo-1 protocol and a 23% rate for the haplo-PC protocol.
• Clinical data includes detailed transplant complications like GVHD and PTLD, which are critical for outcome analysis.
• Statistical methodology is explicitly stated, including the use of Wilcoxon rank-sum and Fisher's exact tests for comparisons.

Limitations

• The dataset is very small at 5.5 KB, indicating a limited sample size and scope.
• Specific row and column counts are unknown, limiting assessment of data structure and granularity.
• Patient exclusions for formal analyses, such as those not receiving PT-Cy or having a second transplant, may introduce selection bias.

Provenance

Source

figshare

Collection Method

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