Transcriptome-Wide Association Study Data for PCIF1 Gene in Bone Homeostasis

TWAS analysis data identifies the PCIF1 gene as a regulator of human bone mineral traits and mesenchymal stem cell differentiation. The dataset contains results from multiple complementary analyses including GWAS, TWAS, and single-cell transcriptomics. Wei Song authored this dataset, which was last updated in April 2026.

Use Cases

• Identify genetic associations between PCIF1 expression and bone mineral density traits using TWAS results.
• Analyze the correlation between PCIF1-mediated m6Am modification and expression levels of Wnt-pathway genes like WNT11, FZD4, and FGFR2.
• Validate findings from mouse models of Pcif1 knockout by comparing them to human GWAS and single-cell transcriptomics data.
• Investigate the role of PCIF1 in early-stage mesenchymal differentiation using the provided transcriptomic associations.

Strengths

• Integrates results from three distinct analysis methods: GWAS, TWAS, and single-cell transcriptomics.
• Data is associated with a specific, peer-reviewed biological mechanism involving m6Am RNA methylation and Wnt signaling.

Limitations

• The dataset is very small at 19.8 KB, indicating limited scope, likely containing summary statistics rather than raw data.
• Specific row counts, column names, and sample sizes for the underlying analyses are not provided.
• The data's primary focus is on a single gene (PCIF1) and its role in bone, limiting broader genomic applications.

Provenance

Source

Figshare, authored by Wei Song.

Collection Method

Results from transcriptome-wide association study (TWAS) and complementary genomic analyses (GWAS, single-cell RNA-seq).

Freshness

Last updated in April 2026.