Structural Data for S1PR1 Agonist Selectivity Analysis

70.5 KB of underlying data for figures 3E–3L from a study on sphingosine-1-phosphate receptor selectivity. The dataset, authored by Lei Yu and shared on figshare under CC-BY-4.0, was last updated on April 10, 2026. It supports findings from cryo-electron microscopy structures, molecular dynamics simulations, and pharmacological assays.

Use Cases

• Analyze agonist selectivity patterns based on structural features of the ligand-binding pocket.
• Validate molecular dynamics simulation results based on cryo-EM structural data.
• Train models to predict agonist binding affinity based on nonconserved residue interactions.
• Compare agonist binding orientations toward transmembrane helices 5–7 across receptor subtypes.

Strengths

• Data is directly linked to published structural analysis and pharmacological assays.
• Available under a permissive CC-BY-4.0 license for reuse.
• File size of 70.5 KB indicates a focused, manageable dataset.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset's scope is limited to supporting specific figures from a single study.

Provenance

Source

figshare

Collection Method

Likely contains processed data from cryo-electron microscopy, molecular dynamics simulations, and pharmacological assays.

Time Range

null

Freshness

Last updated 2026-04-10 17:44:56; freshness should be verified.

Geography

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