ICG Dose and Injection Speed Effects in Thoracoscopic Segmentectomy

30 patients underwent a two-stage study evaluating indocyanine green (ICG) administration during thoracoscopic segmentectomy. The dataset contains measurements of blood ICG concentration and fluorescence intensity across three experimental groups (L, H, F). Results indicate injection speed affects blood concentration but not fluorescence intensity, with a clinical recommendation for a 300 mL/h infusion rate.

Use Cases

• Compare maximum blood ICG concentration values across dose groups (L, H, F) to analyze pharmacokinetic effects.
• Analyze fluorescence intensity measurements at the end of marking to assess visualization quality.
• Investigate the relationship between ICG dose (0.1 mg/kg vs. 0.2 mg/kg) and the duration of observable fluorescence.
• Model the impact of administration rate (300 mL/h vs. 900 mL/h) on achieving target blood concentration ranges (5–10 mg/L).

Strengths

• Data originates from a controlled, single-center clinical study involving 30 human patients.
• Includes specific pharmacokinetic measurements such as maximum blood concentration (e.g., 9.5 mg/L in group F) and fluorescence intensity (e.g., 123.4 in group L).
• Clear experimental design with two stages investigating dose and injection speed variables across three defined groups.

Limitations

• Small sample size of 30 patients limits statistical power and generalizability of findings.
• Single-center study design may introduce institutional or procedural biases not present in broader populations.
• Dataset is very small (9.5 KB), indicating limited scope and likely a summary of key results rather than raw, granular data.

Provenance

Source

figshare, author Noriyuki Misaki.

Collection Method

Data collected from a two-stage clinical study (UMIN-CTR No UMIN000047255) during thoracoscopic segmentectomy procedures.

Time Range

null

Freshness

Last updated March 2026.

Geography

Single-center study; specific location unknown.