Variance Analysis of Response Surface for Cefotaxime Sodium Synthesis

A 5.5 KB Excel dataset containing results from a response surface methodology study to optimize the synthesis of cefotaxime sodium (CTX). The data, authored by Wang Yizhang and last updated in May 2026, details experimental factors like reaction temperature, eluent dosage, and salt-forming agent ratio, with yield and product quality as responses. The study validated optimal conditions achieving a 93.66% yield and a 94.44 green chemistry evaluation score.

Use Cases

• Build a predictive model for pharmaceutical yield based on reaction temperature, eluent dosage, and salt-forming agent ratio.
• Analyze trade-offs between product yield and impurity content using the reported HPLC results.
• Benchmark green chemistry performance scores against other synthesis processes.
• Validate response surface methodology models for chemical process optimization.

Strengths

• Specific optimal conditions are provided: reaction temperature 14.8°C, eluent dosage 104.4 mL, and salt-forming agent ratio 1:1.
• Validation metrics are concrete: a yield of 93.66%, total impurity content of 3.93%, and a green chemistry score of 94.44.
• Multiple analytical methods (HPLC, XRD, SEM) were used for characterization, suggesting rigorous validation.

Limitations

• The dataset is very small at 5.5 KB, indicating limited scope.
• Row count and specific column-level documentation are unknown, requiring inspection after download.
• The description is detailed but lacks the raw experimental data or model coefficients.

Provenance

Source

Wang Yizhang via figshare

Collection Method

Generated via Box-Behnken response surface methodology experiments and subsequent HPLC, XRD, and SEM analysis.

Freshness

Last updated 2026-05-14 17:29:30.