Vascular Remodelling: Agent-Based Model of Tumor-Vessel Interactions

Nicholas Fan developed a multiscale agent-based model to investigate mechanical interactions between proliferating tumor cells and surrounding vasculature. The model simulates vessel deformation, occlusion, and angiogenesis, impacting oxygen supply, tumor growth dynamics, and response to radiotherapy. The dataset, last updated in May 2026, contains simulation outputs from this model.

Use Cases

• Simulating tumor growth dynamics based on mechanical cell-vessel interactions described in the model.
• Studying hypoxia and angiogenesis patterns based on simulated vessel compression and pruning.
• Analyzing radiotherapy treatment efficacy based on simulated post-treatment tumor regrowth linked to vascular landscapes.
• Quantifying spatial tumor vascularisation using the cross-pair correlation function mentioned in the description.

Strengths

• Model incorporates two distinct mechanical forces (Stokes' drag and friction) to represent cell-microenvironment interactions.
• Extensive numerical simulations were performed to investigate parameter influence on tumor vascularisation.
• The dataset is licensed under CC-BY-4.0, allowing for open reuse and modification.

Limitations

• Dataset size is 33.5 KB, indicating a very limited scope of simulation outputs.
• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The description focuses on the model methodology; specific data content and structure must be inferred.

Provenance

Source

figshare

Collection Method

Output from a computational multiscale agent-based model.

Freshness

Last updated 2026-05-15 17:47:51