HIV-1 Infectivity and p24 Secretion Correlation Data

A tabular dataset from a high-content imaging reporter assay using modified GHOST cells to study HIV-1 replication dynamics. The data enables direct correlation between viral infectivity and p24 secretion, providing insights into infection kinetics and ART effects. The dataset is licensed under CC BY 4.0 and was authored by Teresa LuPone.

Use Cases

• Correlate viral infectivity measurements with p24 secretion levels to model HIV-1 replication kinetics.
• Analyze the proportion of non-infectious virions across different experimental conditions, such as ART treatment.
• Use infectivity and p24 data to benchmark the efficiency of viral replication in distinct cell populations.
• Train models to predict infectivity outcomes based on p24 secretion metrics from collected supernatants.

Strengths

• Data generated from a high-content imaging assay designed for consistency and replicability across large numbers of samples.
• Enables direct correlation between two key virology metrics: infectivity and p24 secretion.
• Dataset is openly shared under a permissive CC BY 4.0 license.

Limitations

• The dataset is very small at 285.9 KB, indicating limited scope and sample size.
• Data format is PZFX (GraphPad Prism), requiring specific software for access and analysis.
• Row and column counts are unknown, making it difficult to assess the dataset's structure and analytical potential.

Provenance

Source

figshare, authored by Teresa LuPone.

Collection Method

Data from a modified high-content imaging reporter assay using HIV-1 receptor-expressing GHOST cells.

Time Range

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Freshness

Last updated in March 2026.

Geography

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