P62 Article: Research on Cardiac Hypoxia and p62 Protein in Murine Models

A research article investigating the role of the p62 protein in cardiac physiology under hypoxic conditions. The study uses murine models and H9c2 cardiomyoblasts to examine p62's impact on Hif-1α and Nrf2 signaling pathways. The author is Rajeshwary Ghosh, and the file was last updated on 2026-05-27.

Use Cases

• Analyze the role of p62 in hypoxia-induced cardiac pathology based on the described murine models.
• Study the relationship between p62 deletion and impaired Hif-1α/Nrf2 signaling based on the described transcriptomic and mechanistic analyses.
• Investigate Nrf2-Keap1 co-localization and ubiquitination in p62-deficient cells based on the described cellular experiments.

Strengths

• The description provides a detailed mechanistic hypothesis and experimental findings.
• The dataset is shared under a permissive CC-BY-4.0 license.
• The file is a 1.8 MB PDF, indicating a document of moderate length.

Limitations

• The dataset is a single PDF article, not a structured data file for direct computational analysis.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Likely contains experimental data and analysis from a biomedical research study.

Freshness

Last updated 2026-05-27 14:21:09; freshness should be verified.