PCSK6 in Arteriovenous Fistula Remodeling: Human and Murine VSMC Data

1.9 MB of image data from a study investigating the role of proprotein convertase subtilisin/kexin type 6 (PCSK6) in arteriovenous fistula (AVF) stenosis. The dataset, authored by Xiangjiang Guo and last updated in May 2026, includes findings from human and murine models showing PCSK6 upregulation correlates with neointimal hyperplasia severity.

Use Cases

• Validate PCSK6 expression patterns in vascular smooth muscle cells (VSMCs) based on the described human and murine models.
• Study the correlation between PCSK6 levels and neointimal hyperplasia severity mentioned in the description.
• Investigate the PCSK6/STAT1 signaling axis as a mechanistic driver of VSMC phenotypic switching.
• Assess in vivo outcomes of PCSK6 knockout on AVF lumen diameter and blood flow as described.

Strengths

• Data is openly licensed under CC-BY-4.0.
• Study includes validation across both human samples and murine in vivo models, as described.

Limitations

• Dataset size is small at 1.9 MB, suggesting limited scope.
• Row count and column-level documentation are unknown, limiting suitability assessment.
• The primary file format is JPG, which may contain visualizations rather than raw experimental data.

Provenance

Source

figshare

Collection Method

Experimental research involving in vitro assays and in vivo mouse models, as described.

Freshness

Last updated 2026-05-06 03:40:04.