Pd(0)-Catalyzed Cycloaddition Reaction Data for Aurone-Fused Bis-spirooxindoles

17.8 MB of data on a palladium-catalyzed [3+2] cycloaddition reaction developed by Kiruthika Nachimuthu. The dataset, last updated on 2026-05-25, likely contains experimental results for synthesizing aurone-fused bis-spirooxindoles with four contiguous stereocenters. The protocol uses dppp ligand in acetonitrile and is described as scalable and operationally simple.

Use Cases

• Optimizing reaction conditions for spirocyclic synthesis based on the described scalable protocol.
• Analyzing substrate compatibility for Pd(0)-catalyzed cycloadditions based on the mention of broad tolerance.
• Designing new ligands for stereoselective synthesis based on the use of dppp.
• Identifying functional group compatibility in complex reactions based on the described protocol.
• Building libraries of rigid, three-dimensional molecular architectures for medicinal chemistry screening.

Strengths

• Dataset size is 17.8 MB, indicating a substantial collection of experimental data.
• The described method features operational simplicity, scalability, and compatibility with diverse functional groups.
• The protocol delivers rigid, three-dimensional architectures of potential medicinal relevance.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Kiruthika Nachimuthu via figshare

Collection Method

Likely contains experimental data from a developed Pd(0)-catalyzed cycloaddition reaction.

Freshness

Last updated 2026-05-25 12:05:16; freshness should be verified.