Pd(0)-Catalyzed Cycloaddition Reaction Data for Aurone-Fused Bis-spirooxindoles

A dataset describing a palladium-catalyzed [3+2] cycloaddition reaction between spirovinylcyclopropyl-2-oxindoles and aurones. The protocol, developed by Kiruthika Nachimuthu, yields complex bis-spirooxindole structures with four contiguous stereocenters. The dataset was last updated on May 25, 2026.

Use Cases

• Optimizing reaction conditions for spirooxindole synthesis based on the described catalytic protocol.
• Designing new spirocyclic compounds for medicinal chemistry based on the described rigid, three-dimensional architectures.
• Benchmarking synthetic methods for diastereoselective access to complex frameworks based on the operational simplicity and scalability described.
• Evaluating ligand and solvent compatibility in Pd-catalyzed cycloadditions based on the use of dppp ligand in acetonitrile.

Strengths

• The described method tolerates a broad range of substrates, suggesting diverse experimental data.
• The protocol features operational simplicity and scalability, indicating practical and reproducible data.
• The dataset is 7.8 MB in size, suggesting a contained download.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Kiruthika Nachimuthu

Collection Method

Likely contains experimental data from a developed Pd-catalyzed cycloaddition reaction.

Freshness

Last updated 2026-05-25 12:05:17; freshness should be verified.