Data from a study presenting an on-resin late-stage dual-modification approach for peptides. The method involves copper-catalyzed S-alkynylation of resin-bound peptide thiosulfonates followed by an iridium-catalyzed azide-alkyne click reaction. The dataset, harvested by heiDATA from Dataverse, was last updated on July 12, 2026.
Use Cases
- Modeling peptide-protein interactions based on the described dual-modification chemistry.
- Training models for structure-activity relationship prediction of triazole-containing peptide protease inhibitors.
- Analyzing the modularity of chemical modifications based on the compatibility with various alkynes and azides mentioned.
- Benchmarking computational methods for designing peptides with complex non-canonical modifications.
Strengths
- Methodology is described as highly modular and compatible with a wide range of alkynes and azides.
- Demonstrated application on a complex 34-amino-acid WW domain peptide.
Limitations
- Row count is unknown, which may limit suitability assessment.
- Column-level documentation is absent; field semantics must be inferred after download.
Provenance
- Source
- heiDATA Harvested Dataverse
- Collection Method
- On-resin chemical synthesis and analysis, likely from laboratory experiments.
- Freshness
- Last updated 2026-07-12 07:10:12; freshness should be verified.