Peptidomics and Beyond: Metabolomics Data for Medium-Molecular-Weight Compounds

63 protein-derived peptide fragments and two unknown medium-molecular-weight compounds were identified in plasma samples from hyperlipidemia patients. The dataset was generated by Tomoaki Nitta using a novel capillary electrophoresis–mass spectrometry platform with a 60-fold increased injection volume. It was last updated on 2026-05-27.

Use Cases

• Identify novel peptide biomarkers based on the 63 protein-derived fragments discovered in patient plasma.
• Validate analytical platforms for metabolomics based on the described CE-HRMS method with large-volume dual preconcentration.
• Investigate the role of medium-molecular-weight compounds in disease pathology based on the elevated levels of bradykinin, CLIP, and schizophrenia-related peptides.

Strengths

• Detection limits of 10 pg/mL for peptides like bradykinin and ANP were achieved.
• The platform enabled a 60-fold increase in injection volume over standard methods.
• The dataset includes findings from plasma samples of hyperlipidemia patients.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small at 104.9 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Developed using capillary electrophoresis coupled with high-resolution mass spectrometry (CE–HRMS) with large-volume dual preconcentration by isotachophoresis and stacking (LDIS).

Freshness

Last updated 2026-05-27 08:05:02; freshness should be verified.