Peptidomimetic GHRH Agonist Structures for Hindlimb Ischemia Study

A series of hybrid peptide structures developed through sulfono-γ-AA peptidomimetic optimization. The dataset contains Protein Data Bank (PDB) files for long-acting growth hormone-releasing hormone receptor agonists tested in a mouse model of hindlimb ischemia. It was authored by Haodong Shao and last updated on figshare in April 2026.

Use Cases

• Molecular docking studies based on the described peptidomimetic structures
• Analyzing structure-activity relationships for GHRH receptor agonists based on the hybrid peptide design
• Modeling angiogenesis and tissue repair pathways based on the described ERK signaling activation
• Studying protein stability and half-life based on the reported serum stability (>24 hours)

Strengths

• File format is PDB, a standard for 3D structural data.
• Dataset is focused on a specific therapeutic application (hindlimb ischemia) with described in vitro and in vivo results.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (581.0 KB), indicating limited scope.

Provenance

Source

figshare, authored by Haodong Shao.

Collection Method

Data appears to be generated from experimental research on peptide design and preclinical testing.

Time Range

The study timeframe is not specified.

Freshness

Last updated 2026-04-13 17:35:21; freshness should be verified.

Geography

The geographic scope of the research is not specified.