Peptidomimetic GHRH Agonist Data for Hindlimb Ischemia in Mice

16.2 KB of tabular data from a 2026 figshare upload details hybrid peptide analogs designed for long-acting growth hormone-releasing hormone receptor activation. Haodong Shao authored this dataset, which likely contains results from in vitro and in vivo experiments measuring peptide stability, potency, and therapeutic effects. The data underpins findings that these peptides enhance blood perfusion and tissue repair in a mouse model of hindlimb ischemia.

Use Cases

• Modeling peptide structure-activity relationships based on sulfono-γ-AA peptidomimetic optimization described.
• Analyzing correlations between serum stability (T1/2 > 24 h) and in vivo therapeutic outcomes.
• Investigating ERK signaling pathway activation in endothelial cells based on the described in vitro mechanism.
• Evaluating metrics for vascular remodeling and collateral vessel formation in ischemic tissue repair.

Strengths

• Dataset is small (16.2 KB), facilitating quick download and initial inspection.
• Includes a specific, promising therapeutic finding: peptides demonstrated serum stability with T1/2 > 24 hours.
• Data is associated with a detailed scientific description outlining the experimental context and key results.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data scale is very limited (16.2 KB), suggesting a focused experimental snapshot rather than a broad collection.

Provenance

Source

figshare, uploaded by author Haodong Shao.

Collection Method

Likely contains experimental data from in vitro assays and mouse model studies of hindlimb ischemia.

Time Range

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Freshness

Last updated 2026-04-13 17:35:22; freshness should be verified.

Geography

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