Heptamethine Cyanine Dyes Interaction Data with BSA and HPA Proteins

Aggregating molecular interaction data for six designed heptamethine cyanine dyes (TEA1–6) with bovine serum albumin (BSA) and human parvalbumin (HPA) proteins. It documents photophysical properties, including absorption and fluorescence quenching in aqueous solutions, and the reversal of quenching upon protein addition. The data supports the study of peptide-like substituents for enhancing protein recognition in bioimaging applications.

Use Cases

• Analyze the relationship between dye structure (e.g., amide linkages, amino acid moieties) and fluorescence quenching reversal upon addition of BSA or HPA.
• Model binding interactions between the six cyanine dyes and the proteins BSA and HPA to predict protein recognition.
• Study the photophysical properties, such as strong absorption and NIR-emitting capabilities, of the six synthesized dyes in different environments.
• Investigate the hypothesis that aggregates formed in aqueous solutions are disrupted by protein interactions, using the provided interaction data.

Strengths

• Data is derived from six specifically designed and synthesized heptamethine cyanine dyes (TEA1–6).
• Interaction studies were conducted with two distinct biological proteins: bovine serum albumin (BSA) and human parvalbumin (HPA).
• The dataset captures a specific photophysical phenomenon: nonfluorescent behavior in aqueous solutions reversed upon protein addition.

Limitations

• The dataset is very small, with a file size of only 963.0 B, indicating limited scope and detail.
• The number of data rows and specific columnar features are unknown, limiting analytical depth.
• The data is focused on a specific, controlled laboratory study, which may not generalize to other proteins or biological contexts.

Provenance

Source

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Collection Method

Data from the design, synthesis, and photophysical study of six heptamethine cyanine dyes, followed by interaction testing with BSA and HPA proteins.

Time Range

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Freshness

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Geography

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