PFAS Mixture Composition and Biological Responses in Fathead Minnows Under Field Exposure

Multi-year field exposures from 2018, 2019, and 2021 of male fathead minnows to PFAS-contaminated groundwater from Joint Base Cape Cod, Massachusetts. The dataset, authored by Alan M. Vajda and shared via figshare, includes biological response data and transcriptomics results linking internal PFAS profiles to organismal outcomes.

Use Cases

• Modeling mixture-dependent biological effects based on PFAS composition and concentration differences.
• Analyzing links between internal PFAS exposure profiles and organismal outcomes like mortality and reproductive impairment.
• Studying the disruption of metabolic, mitochondrial, and endocrine pathways in liver tissue from transcriptomic data.
• Comparing biological responses between PFOS-dominated and PFOA/precursor-enriched PFAS mixtures.

Strengths

• Data originates from multi-year (2018, 2019, 2021) continuous-flow, field-based exposures, providing realistic environmental context.
• Includes measurements from distinct PFAS mixture compositions (PFOS-dominated vs. PFOA/precursor-enriched) enabling separation of concentration and mixture effects.
• Integrates organismal outcomes (mortality, sex traits, sperm motility) with plasma PFAS profiles and liver/testis transcriptomics.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Continuous-flow, field-based exposures of male fathead minnows using groundwater from a reference well and PFAS-contaminated wells at Joint Base Cape Cod, Massachusetts.

Time Range

2018, 2019, 2021

Freshness

Last updated 2026-05-24 13:05:24; freshness should be verified.

Geography

Joint Base Cape Cod, Massachusetts, USA