Photoredox-Catalyzed Annulation Reaction Data for Pharmaceutical Synthesis

45.3 MB of data describes a catalytic radical–polar crossover annulation reaction between N-arylglycines and β-silylmethylene malonates/aryl/alkylidene malonates. The dataset likely contains experimental results for synthesizing silyl/aryl/alkyl-substituted N-aryl γ-lactams, with yields and diastereoselectivities. It was authored by Raghunath Chowdhury and last updated on May 8, 2026.

Use Cases

• Analyze reaction yields and diastereoselectivities based on the described catalytic protocol
• Benchmark synthetic methods for γ-lactam derivatives based on the described substrate combinations
• Validate synthetic pathways for pharmaceutical drugs like (±)-oxiracetam and (±)-pregabalin based on the described expedient synthesis

Strengths

• Dataset size is 45.3 MB, indicating a substantial amount of data
• The described method achieved good to excellent yields and diastereoselectivities under mild conditions

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

figshare

Collection Method

Likely contains experimental data from the developed catalytic protocol

Freshness

Last updated 2026-05-08 13:39:59