Platelet Reactivity and Biomarker Data from Coronary Artery Spasm Patients

A clinical study from The University of Adelaide investigates platelet nitric oxide signaling impairment in coronary artery spasm patients. It compares patients during acute symptomatic crises and chronic phases against healthy controls, measuring plasma biomarkers like syndecan-1, tryptase, and platelet microparticles. The research explores the therapeutic role of N-acetylcysteine and hydrogen sulfide donors in reversing observed platelet resistance.

Use Cases

• Modeling platelet responsiveness to nitric oxide donors based on patient clinical phase
• Analyzing correlations between plasma biomarker levels (syndecan-1, tryptase, microparticles) and symptomatic crises
• Investigating the therapeutic effect of N-acetylcysteine and hydrogen sulfide donors on platelet signaling pathways

Strengths

• Data includes comparisons between acute symptomatic crises, chronic phases, and healthy control subjects
• Measures multiple specific plasma biomarkers: syndecan-1, tryptase, and platelet microparticles
• Investigates a therapeutic intervention (N-acetylcysteine infusion) and its proposed mechanism via hydrogen sulfide

Limitations

• Description metadata is limited; actual data quality requires manual inspection after download
• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

The University of Adelaide

Collection Method

Clinical evaluation of patients during acute/chronic phases, with laboratory measurements of platelet aggregation inhibition and plasma biomarkers.