Platinum(II) Complexes Conjugated to O-Glycosides: Synthesis and Antitumor Activity

Two platinum(II) complexes, cis-[PtCl2(C6H14S2O2)-κ2S] and cis-[PtCl2(C26H38O12S2)-κ2S], were synthesized and evaluated for toxicity and antitumor activity. The glycosidic complex was classified in a lower toxicity category than its analogous system, demonstrating reduced toxicity. Both complexes showed tumor inhibition percentages of 57% and 59%, respectively, similar to cisplatin's 59%, while the glycosidic ligand alone showed only 38% inhibition.

Use Cases

• Compare toxicity profiles of platinum complexes based on OECD protocol categories mentioned in the description
• Evaluate antitumor efficacy of synthesized compounds based on percent inhibition data from mouse models
• Investigate the role of platinum ions in antitumor action based on comparisons with ligand-only activity
• Analyze structure-activity relationships for glycoside-conjugated metal complexes

Strengths

• Specific antitumor activity percentages (57%, 59%, 38%) are reported for direct comparison
• Complexes are classified into specific OECD acute toxicity categories (3 and 4)
• Direct comparison of activity is made to the standard chemotherapeutic agent cisplatin

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Last update date is unknown; freshness unverified

Provenance

Source

Lidiane M. A. de Lima via paperswithcode

Collection Method

Likely contains experimental synthesis and biological assay results.