Aryl-Daptomycin Derivatives: Antibacterial and Antibiofilm Activity Data

A library of aryl-Daptomycin compounds constructed by postmodification at the tryptophan residue. The dataset likely contains experimental results for a lead compound, 1i, comparing its antibacterial activity, antibiofilm efficacy, and stability against Daptomycin. The data was uploaded by Tiantian Yan on figshare in May 2026.

Use Cases

• Evaluating novel antibiotic efficacy based on antibacterial activity data
• Studying biofilm inhibition mechanisms based on agr system and ica gene downregulation data
• Comparing compound stability based on molecular dynamics simulation results
• Assessing in vivo performance in mouse infection models based on bacterial count and biofilm burden reduction data

Strengths

• Data includes in vivo study results from mouse models of skin wound and catheter-related infection
• Mechanistic studies provide insights into membrane disruption and gene regulation
• File size is 11.4 KB, indicating a focused and potentially easily processed dataset

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Description metadata is limited; actual data quality requires manual inspection after download

Provenance

Source

figshare

Collection Method

Experimental synthesis and testing of a library of aryl-Daptomycin derivatives.

Freshness

Last updated 2026-05-26 11:45:56; freshness should be verified