Potent Anthranilic Anilide-Based TRPM4 Channel Inhibitors from SAR Study

Christian E. Gerber published a dataset on figshare in April 2026 detailing novel anthranilic anilide-based TRPM4 channel inhibitors. The 6.3 KB CSV file contains results from a structure–activity relationship (SAR) study that identified compound PBA (118), which exhibits increased potency and lower cytotoxicity compared to a reference inhibitor. The data includes findings on scaffold modifications, substitution effects, and structural analyses supporting future TRPM4 drug development.

Use Cases

• Train quantitative structure-activity relationship (QSAR) models based on the reported SAR study results.
• Benchmark new TRPM4 inhibitor candidates against the reported potency and ligand efficiency metrics.
• Analyze the relationship between lipophilic groups and inhibitor potency based on the described substitution effects.
• Investigate molecular conformation patterns for anthranilic anilides based on the described X-ray and NMR structural findings.

Strengths

• Dataset is explicitly linked to a published scientific study with a specific compound identifier (PBA/118).
• Description details concrete chemical properties like aqueous solubility, lipophilic ligand efficiency, and cytotoxicity.
• File is a small 6.3 KB CSV, ensuring quick download and easy initial inspection.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality and completeness require manual inspection.

Provenance

Source

figshare

Collection Method

Likely contains experimental and computational results from a focused structure-activity relationship study.

Time Range

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Freshness

Last updated 2026-04-13 07:39:08; freshness should be verified.

Geography

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