ppat.1013974.t002: Ubiquitylated Peptides in Mtb-Infected Macrophages

Tina Truong's dataset from 2026 contains mass spectrometry results from Mycobacterium tuberculosis-infected macrophages. It includes over 46,000 ubiquitylated peptides, with roughly 400 showing CBL-dependent ubiquitylation. The data was used to identify the Fas-associated factor 2 (FAF2) adapter protein as a key signaling regulator.

Use Cases

• Identify potential ubiquitin ligase substrates based on the over 46,000 ubiquitylated peptides.
• Analyze CBL-dependent signaling events based on the roughly 400 peptides with CBL-dependent ubiquitylation.
• Investigate the regulation of antiviral response genes in infected macrophages as described in the study.
• Perform genetic interaction analysis on putative substrates like the FAF2 adapter protein.

Strengths

• Contains over 46,000 ubiquitylated peptides identified by mass spectrometry.
• Includes roughly 400 peptides with CBL-dependent ubiquitylation.
• Data is openly available under a CC-BY-4.0 license.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 9.5 KB, indicating limited scope.

Provenance

Source

figshare, author Tina Truong.

Collection Method

Data generated via mass spectrometry on Mycobacterium tuberculosis-infected macrophages.

Time Range

Publication date implied by 2026 update.

Freshness

Last updated 2026-03 17:36:52; freshness should be verified.

Geography

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